Steroidal Saponins from Paris Polyphylla Suppress Malignancy of Human Lung Cancer A549 Cells
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چکیده
Lung cancer is the leading causes of cancer death worldwide (Siegel et al., 2014), mainly due to the difficulty of early diagnosis and the highly metastatic potential, which has being the hotspot of lung cancer research (Li et al., 2014). In fact, the metastasis has already developed before the diagnosis of lung cancer in most cases, for example, approximately 30 to 40% of patients with advanced lung cancer will develop bone metastases (Sone and Yano, 2007; Al Husaini et al., 2009). More than 90% of lethality in cancer patients is caused by metastasis and the occurrence of distant metastases resulting in a significant poor prognosis of lung cancer patients (Cheng et al., 2014). For metastasis, tumor cells invade through the basement membrane, enter the vasculature, survive without adhesion, disseminate into the circulation, and finally establish a new tumor in another organ. For migration, the cell body must modify its shape and stiffness to interact with the surrounding tissue structures. Hereby, the extracellular matrix (ECM) provides the substrate, as well as a barrier towards the advancing cell body (Friedl and Wolf, 2003; Yilmaz et al., 2007; Al Husaini et al., 2009). Depending on the tumor type and the surrounding
منابع مشابه
Steroidal saponins from Paris polyphylla induce apoptotic cell death and autophagy in A549 human lung cancer cells.
BACKGROUND Paris polyphylla (Chinese name: Chonglou) had been traditionally used for a long time and shown anti-cancer action. Based on the previous study that paris polyphylla steroidal saponins (PPSS) induced cytotoxic effect in human lung cancer A549 cells, this study was designed to further illustrate the mechanisms underlying. MATERIALS AND METHODS The mechanisms involved in PPSS-induced...
متن کاملIn-vitro Antitumor Activity and Antifungal Activity of Pennogenin Steroidal Saponins from paris Polyphylla var. yunnanensis
Paris polyphylla Smith var. yunnanensis, has been used in traditional Chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. In this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the EtOH extract of Paris polyphylla var. yunnanensis, and then tested for their antit...
متن کاملIn-vitro Antitumor Activity and Antifungal Activity of Pennogenin Steroidal Saponins from paris Polyphylla var. yunnanensis
Paris polyphylla Smith var. yunnanensis, has been used in traditional Chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. In this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the EtOH extract of Paris polyphylla var. yunnanensis, and then tested for their antit...
متن کاملThe anti-lung cancer activities of steroidal saponins of P. polyphylla Smith var. chinensis (Franch.) Hara through enhanced immunostimulation in experimental Lewis tumor-bearing C57BL/6 mice and induction of apoptosis in the A549 cell line.
P. polyphylla Smith var. chinensis (Franch.) Hara (PPSCFH) has been used as medicinal Paris for the prevention and treatment of cancers in China for thousands of years. Its main components, steroidal saponins (PRS), have been confirmed to inhibit tumor growth. In the present study, the immunostimulation of PRS was investigated in Lewis bearing-C57BL/6 mice while the induction of apoptosis in A5...
متن کاملIn-vitro Antitumor Activity and Antifungal Activity of Pennogenin Steroidal Saponins from paris Polyphylla var. yunnanensis
Paris polyphylla Smith var. yunnanensis, has been used in traditional Chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. In this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the EtOH extract of Paris polyphylla var. yunnanensis, and then tested for their antit...
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